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Clinical, Histochemical, and Microscopic Study

NEILL B. REWCASTLE, MB, Ch B; JOHN G. HUMPHREY, FRCP(C)

Arch Neurol. 1965;12(6):570-582.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

O CCASIONAL vacuolated muscle fibers may occur in any myopathy. Widespread vacuolation of muscle fibers occurs in familial periodic paralysis but only rarely has it been reported in other myopathies. Unverricht¹² described such a myopathy in 1891 and noted the absence of muscle-fiber regeneration. More recently, the absence of other structural changes in muscle fibers and the lack of focal inflammatory cell infiltrations have been noted in vacuolar myopathies by Pearson⁸ and Denny-Brown.³ Such myopathies have been reported in association with systemic lupus erythematosus,⁸ rheumatoid arthritis, and carcinoma and following adrenosteroid therapy,¹ or prolonged chloroquine phosphate therapy.¹⁵

This report is the summary of the clinical features of a case of vacuolar myopathy associated with systemic lupus erythematosus and prolonged chloroquine therapy. Light- and electron-microscopic appearances of the myopathy have been studied from biopsy specimens before and after discontinuation of the chloroquine and institution of . . . [Full Text PDF of this Article]

Author Affiliations
TORONTO

From the Division of Neuropathology, Department of Pathology and the Department of Medicine, University of Toronto and the Toronto General Hospital; Medical Research Fellow, Medical Research Council, Canada (Dr. Rewcastle); Clinical Teacher, Department of Medicine (Dr. Humphrey).

Footnotes
Submitted for publication Jan 11, 1965; accepted Feb 4.

Reprint requests to 100 College St, Toronto 2, Canada (Dr. Rewcastle).

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