This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (15)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Observations on the Effect of Penicillamine, Carbacrylamine Resins, and Potassium Sulfide

NORMAN P. GOLDSTEIN, MD; RAYMOND V. RANDALL, MD; JOHN B. GROSS, MD; WARREN F. McGUCKIN, PhD

Arch Neurol. 1965;12(5):456-462.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A LTHOUGH it is generally recognized that Wilson's disease (hepatolenticular degeneration) is a genetic disorder involving a disturbance of the metabolism of copper, there are few reports related to studies of copper balance.^1-3 Available data indicate that patients who have this disorder absorb greater than normal amounts of copper from the gastrointestinal tract⁴ and excrete less than normal amounts in the feces.⁵ However, the mechanisms of intestinal absorption and fecal excretion of copper remain obscure, both in normal individuals and in patients with this illness.

The treatment of Wilson's disease with penicillamine is known to increase the urinary excretion of copper.^6,7 Likewise, it has been stated that the oral use of either ion-exchange resins^8,9 or potassium sulfide^10,11 at mealtime increases the fecal content of copper. In view of the derangement of copper metabolism in this illness, treatment should be aimed at achieving a negative . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER. MINN

From the Mayo Clinic and Mayo Foundation. Section of Neurology (Dr. Goldstein); Section of Medicine (Drs. Randall and Gross); Section of Biochemistry (Dr. McGuckin).

Footnotes
Submitted for publication April 15, 1964; accepted Jan 11, 1965.

Read by title at the meeting of the American Neurological Association, Atlantic City, NJ, June 10-12, 1963.

Reprint requests to Mayo Clinic, Rochester, Minn 55901.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?