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Hypertonic Urea in Experimental Cerebral Edema
RAYMOND A. CLASEN, MD;
PAULINE M. COOKE, MD;
SYLVIA PANDOLFI;
GEORGE CARNECKI, BS;
GEORGE BRYAR, MD
Arch Neurol. 1965;12(4):424-434.
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Introduction
THE EXPERIMENTS to be reported represent a further continuation in monkeys of work on cerebral injury originally begun in rabbits11 and continued in dogs.4 Our purpose in conducting these experiments has been to evaluate therapeutic measures designed to alleviate the effects of cerebral hemorrhage and edema. To this end, a method was devised of producing areas of hemorrhagic necrosis in the brains of experimental animals by freezing through the exposed intact skull. Quantitative methods were then devised to study the edema and hemorrhage through measurements of water and iron in the damaged tissue.6 An attempt was then made to assess the effects of intravenous hypertonic solutions by means of these methods. Since these lesions were produced through the intact skull with preservation of intracranial fluid dynamics, changes in the cerebrospinal fluid pressure (CSFP) could also be studied. It was found that these lesions were associated
. . . [Full Text PDF of this Article]
Author Affiliations
CHICAGO
From the Division of Pathology, Presbyterian-St. Luke's Hospital. Associate Professor of Pathology, University of Illinois College of Medicine (Dr. Clasen).
Footnotes
Submitted for publication Oct 16, 1964; accepted Dec 14, 1964.
Read before the 37th Annual Meeting of the American Association of Neuropathologists, June 1961.
Reprint requests to 1753 W Congress Pkwy, Chicago, Ill 60612 (Dr. Clasen).
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