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Involvement of Nervous System in Behcet's Syndrome
SHELDON M. WOLF, MD;
DONALD L. SCHOTLAND, MD;
LOUISE L. PHILLIPS, PhD
Arch Neurol. 1965;12(3):315-325.
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THE major features of Behçet's syndrome are recurrent oral and genital ulcers and ocular lesions.10 Many types of ocular involvement have been described, including uveitis, iridocyclitis with hypopyon, keratitis, optic neuritis, and inflammation, thrombosis, or hemorrhage of the blood vessels of the retina.57 Other manifestations of the syndrome have included pyoderma, furunculosis, erythema nodosum, thrombophlebitis, pericarditis, arthritis, hepatomegaly, epididymitis, ulcers of the gastrointestinal tract, and central nervous system disease. The etiology is not known.
The disease may begin with any one of the triad of symptoms, and the complete syndrome may not appear until several years later.57 Curth23 has suggested that the diagnosis is justified when two of the three classic manifestatations are present; this principle has been accepted by others.26,56,58,90,92 Although the course is variable, the illness often abates in 15 to 20 years. Blindness is a frequent sequel.57 When neurologic complications are
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
Footnotes
Submitted for publication Aug 27, 1964; accepted Sept 16.
Neurologist, Southern California Permanente Medical Group, Los Angeles; Instructor in Neurology, University of Southern California, School of Medicine (Dr. Wolf). Associate in Neurology, College of Physicians and Surgeons, Columbia University. Research Associate, Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons (Dr. Phillips).
Reprint requests to 4900 Sunset Blvd, Los Angeles, Calif 90027 (Dr. Wolf).
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