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Histochemical and Cytochemical Localization

EDWARD COTLIER, MD; THEODORE W. LIEBERMAN, MD; ANDREW J. GAY, MD

Arch Neurol. 1965;12(3):294-299.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

A SIX-LAYERED neuronal arrangement is present in the monkey lateral geniculate body. Neurons in laminae 2, 3, and 5 receive ganglion cell axons solely from the ipsilateral eye, while laminae 1, 4, and 6 receive those from the contralateral eye.^4,12 Laminae 1 and 2 are magnocellular (large cells) and 2, 4, 5, and 6 parvocellular (small cells). Adequate comparisons of laminae of similar cytology can be established within each lateral geniculate nucleus. This is of value, particularly in the studies of transneuronal degeneration.^4,5 After uniocular enucleation, only neurons receiving afferent from the corresponding eye demonstrate Nissl and morphologic changes of transneuronal atrophy.

A previous study from this laboratory indicates that the enzymatic activities decrease in the corresponding lateral geniculate nuclear laminae following eye enucleation.⁸ As these histochemical changes precede those in Nissl substance, it may be assumed that enzymatic neuronal activities are affected earlier in this . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Department of Ophthalmology and Neurology, and the Oscar Johnson Institute, Washington University Medical School.

Footnotes
Submitted for publication Aug 8, 1964; accepted Nov 3.

Reprint requests to Washington University Medical School, St. Louis, Mo 63110 (Dr. Cotlier).

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