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Radioactive Uptake Studies With Chloride and Inulin

ANTONIA VERNADAKIS, PhD; DIXON M. WOODBURY, PhD

Arch Neurol. 1965;12(3):284-293.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DURING development of the central nervous system (CNS) both cellular and extracellular spaces and the permeability of the CNS to various substances undergo certain changes. For example, cytological studies have shown that both the number and the volume of glial cells increase with maturation whereas the number of neurons remains constant and only the neuronal volume increases.^2,3 It has also been shown that the brain extracellular space decreases during development.^7,19 Methods for studying the various physiological compartments of the CNS have been developed by Woodbury,²⁰ Reed and Woodbury,¹² and Reed et al.¹³ The rate of entrance of radioactive substances such as sucrose, iodide, chloride, inulin, and bromide into the CNS and their volume of distribution were used to study the various physiological compartments of the brain and the interchange of substances between these compartments. However, such studies have been confined to adult animals and no . . . [Full Text PDF of this Article]

Author Affiliations
SALT LAKE CITY

From the Department of Pharmacology, University of Utah, College of Medicine.

Footnotes
Submitted for publication July 31, 1964; accepted Oct 3.

Reprint requests to Salt Lake City, Utah 84112 (Dr. Woodbury).

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