This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (8)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

ELLIOTT BLINDERMAN, MD

Arch Neurol. 1965;12(3):278-283.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

THE RATIONALE for the use of adrenal steroids in the prevention and treatment of cerebral edema has been based on both experimental studies and clinical observations. Early experimental work¹ showed that steroids could prevent the passage of trypan blue into edematous brain and could help restore a normal electroencephalographic pattern. A clinically smoother postoperative course, reported when patients with craniopharyngiomas were pretreated with steroids,^2,3 was felt to be due to a lessening of postoperative edema. More recent clinical reports have further supported the concept of the usefulness of adrenal steroids in cerebral edema.⁴

Prados¹ and more recently Hatanaka⁵ have proposed that the steroids act directly on the vascular endothelium of the brain whereas Grenell⁶ believed there may be direct action on the cells. A more exact mechanism of action has not been proposed. Indeed, there may be many modes of action of the . . . [Full Text PDF of this Article]

Author Affiliations
LOS ANGELES

From the University of California, Los Angeles, School of Medicine, Department of Surgery/Neurosurgery.

Footnotes
Submitted for publication July 21, 1964; accepted Sept 15.

Reprint requests to Los Angeles, Calif 90024 (Dr. Blinderman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?