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VI. Intracellular Accumulation of Fluid and Cryptococcal Polysaccharide in Oligodendroglia

ASAO HIRANO, MD; H. M. ZIMMERMAN, MD; SEYMOUR LEVINE, MD

Arch Neurol. 1965;12(2):189-196.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

I

Introduction

NTRACEREBRAL implants of cryptococcal or pneumococcal polysaccharides caused intense vacuolation in white matter.¹ Light microscopic and immunofluorescent studies indicated that the polysaccharides spread in white matter for considerable distances.^1,2 In the late stage, the vacuoles were clearly intracellular, and the same location was erroneously inferred for the early stage.¹ Electronmicroscopic studies of the early stage proved that the vacuoles actually constituted greatly distended extracellular spaces filled with polysaccharide-rich fluid.³ Only small amounts of fluid entered cells, either by direct invasion through ruptured cell walls (only in the neighborhood of the implant), or by engulfment in relatively rare phagocytes.⁴ The present work is an electron microscopic study of the subacute and chronic phases of the experiment, phases in which the bulk of the fluid and foreign polysaccharide leave the extracellular spaces to become intracellular. In this work, we focus attention on the oligodendrocyte.

Materials . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Footnotes
Submitted for publication July 25, 1964; accepted Oct 6.

From the Henry and Lucy Moses Research Laboratories of the Laboratory Division, Montefiore Hospital and New York Medical College Center for Chronic Disease. Dr. Hirano is Visiting Scientist, Epidemiology Branch, National Institute of Neurological Diseases and Blindness of the National Institutes of Health, United States Public Health Service.

Reprint requests to 210th St and Bainbridge Ave, New York, NY 10467 (Dr. Zimmerman).

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