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Case Report With Special Emphasis on Associated Pathology of Peripheral Nervous System

HIDEO NAMIKI, MD

Arch Neurol. 1965;12(1):98-107.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1951, Leigh¹ published a case report of a peculiar neuropathological disorder in an infant. The disease, which he called subacute necrotizing encephalomyelopathy, was characterized by (1) multiple, frequently symmetrical foci of necrosis with predilection for the periaqueductal and periventricular structures and the tegmentum of the brain stem, (2) breakdown of the interstitial tissue of the nerve parenchyma with relative preservation of the cell bodies of the neurons, and (3) the prominence of small blood vessels. Although Leigh suggested that the disorder might represent Wernicke's disease in infants, there has been no convincing proof as to the etiology of this disorder. Subsequently, Feigin and Wolf (1954),² Richter (1957),³ and Reye (1960)⁴ added several cases of a similar neuropathological disease.

The case reported here is the first recorded instance of the disease in Japan. The importance of the associated pathology of the peripheral nerves, spinal roots, and . . . [Full Text PDF of this Article]

Author Affiliations
NAGASAKI, JAPAN

From the Department of Pathology, Atomic Bomb Casualty Commission, a research agency of the US National Academy of Sciences-National Research Council.

Footnotes
Submitted for publication Aug 4, 1964; accepted Sept 2.

Under a grant from the US Atomic Energy Commission administered in cooperation with the Japanese National Institute of Health of the Ministry of Health and Welfare.

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