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A New Method for the Repeated Serial Measurement of Total Cerbral Blood Flow Using Iodoantipyrine (1131) With a Report of Determination in Normal Human Beings of Blood Flow, Oxygen Consumption, Glucose Utilization and Respiratory Quotient of the Whole Brain

O. M. REINMUTH, MD; PERITZ SCHEINBERG, MD; BERNADETTE BOURNE, PhD

Arch Neurol. 1965;12(1):49-66.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The traditional measurement of cerebral blood flow (CBF) by the nitrous oxide method of Kety and Schmidt¹ has the two important limitations that flow rates reflect only the average rate over a ten-minute equilibratory period and that the values reflect rates per unit weight of perfused cerebral tissue. The first limitation prevents obtaining quantitative data concerning brain blood flow and metabolism under short-acting stresses and rapidly changing states, while the second may prevent recognition of changes in the total mass of perfused brain.

Wechsler² and Lewis et al³ have recently employed Kr⁷⁹ as the inert gas in CBF determinations, and by virtue of the ability to monitor continuously the brain content of -emitting Kr⁷⁹ by external head scintillation detectors were able to measure minute by minute values of CBF over approximately five minutes of a ten-minute period of Kr⁷⁹ inhalation. This valuable advance in . . . [Full Text PDF of this Article]

Author Affiliations
MIAMI, FLA

From the Department of Neurology, University of Miami School of Medicine.

Footnotes
Submitted for publication July 27, 1964; accepted Sept 14.

Associate Professor of Neurology (Dr. Reinmuth); Professor of Neurology (Dr. Scheinberg); Assistant Professor of Neurology and Biochemistry (Dr. Bourne).

Supported in part by United States Public Health Service research grant HE-06641 (National Heart Institute of the National Institutes of Health) and by research grants of The Greater Miami Heart Association, The Florida Heart Association, and by The Meyer Gold grant.

A part of this subject matter was presented to The General Scientific Session of The American Academy of Neurology, April, 1961.

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