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Isotope Study of Brain Blood Turnover in Vascular Disease
W. H. OLDENDORF, MD;
MASAMI KITANO, MD
Arch Neurol. 1965;12(1):30-38.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Presented here are data concerning brain circulation (pool turnover) time obtained through the application of an intravenous radioisotope technique. We have attempted to establish normal values and to compare these with results obtained from a group of patients with clinically evident cerebrovascular disease.
The technique has been described in detail in an earlier report.1 Briefly, a rapidly excreted  -emitting indicator, I131 iodohippurate, is injected intravenously, and its subsequent passage through the cranial blood pool is monitored by an external detection system. The parameter of this passage most readily derived, as will be shown, is the transit (circulation) time of the cranial blood pool. This transit time is in the range of 6 to 11 seconds in healthy adults with values near the lower extreme of this range in the young and approaching the upper extreme in healthy old age. Our results indicate most patients with a history of
. . . [Full Text PDF of this Article]
Author Affiliations
LOS ANGELES
From the Neurology Section, Medical Service, Wadsworth Hospital, Veterans Administration Center, Los Angeles, Calif, and the Division of Neurology, Department of Medicine, UCLA Center for the Health Sciences.
Footnotes
Read before the Annual Meeting of the American Neurological Association, Atlantic City, NJ, June 17, 1964.
This work was in part supported by US Public Health Service grant No. NB-02575.
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