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Absence of Small Primary Sensory Neurons in Ganglia, Roots, and Lissauer's Tract

AUGUST G. SWANSON, MD; GEORGE COLIN BUCHAN, MD; ELLSWORTH C. ALVORD, JR., MD

Arch Neurol. 1965;12(1):12-18.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Congenital universal insensitivity or indifference to pain has been reported in about 45 cases since Dearborn's¹ first description of a man with unusual tolerance for pain. The emphasis of the reports has varied, and there has been great variation in the completeness of recording of historical, neurological, and biopsy data. As recently as 1961, Kunkle² pointed out that the available information still makes it difficult to determine whether many of the recorded cases are lacking in the ability to perceive pain "insensitivity" or have an abnormal lack of the appreciation of pain "indifference."

Biopsy of peripheral nerves has permitted identification of some cases of peripheral neuropathy,³ but in other cases no such abnormalities have been found.^3,4,5 Only two detailed neuropathologic studies have been reported in cases coming to autopsy^6,7; neither revealed significant abnormalities, so that one is justified in classifying these as cases of congenital . . . [Full Text PDF of this Article]

Author Affiliations
SEATTLE

From the Division of Neurology and the Department of Pathology, University of Washington School of Medicine.

Footnotes
Presented at the annual meeting of the American Neurological Association, Atlantic City, NJ, June, 1963.

John and Mary R. Markle Scholar in Medicine; Associate Professor of Medicine (Neurology), University of Washington (Dr. Swanson); Special Fellow in Neuropathology, supported in part by a Training Grant in Neuropathology (5-T1-NB-5231) from the National Institute of Neurological Diseases and Blindness. National Institutes of Health, US Public Health Service (Dr. Buchan); Professor of Pathology (Neuropathology), University of Washington (Dr. Alvord).

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