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Present Status

CHARLES B. WILSON, MD

Arch Neurol. 1964;11(5):562-568.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Glioblastoma multiforme is a malignant tumor with a uniformly fatal course. Palliation achieved by conventional radiation and surgical techniques can be measured in terms of months. The urgent need for new avenues of approach prompted a review of current laboratory and clinical investigation relating to glioblastomas.

Tissue Culture and Heterotransplantation Neuroglial tumors have been grown by a variety of tissue culture techniques during the past 30 years. Russell and Bland³⁷ studied 20 gliomas in tissue culture and established the basis for their identification and classification in vitro. Lumsden²¹ recently published his extensive experience with the astrocytoma-glioblastoma group of tumors and reviewed previous contributions to this subject. He differentiated normal and neoplastic astrocytes in plasma clot preparations by their rate of migration and by the number and branching of their processes. These observations were made in short-term cultures, and not until 1959 did Manuelidis²⁶ report long-term culture of . . . [Full Text PDF of this Article]

Author Affiliations
LEXINGTON, KY

From the Department of Surgery, Division of Neurosurgery, University of Kentucky Medical Center.

Footnotes
Read before the meeting of the Southern Neurosurgical Society, St. Louis, Feb 20-22, 1964.

Assistant Professor and Chairman, Division of Neurosurgery.

Supported by Kentucky Division of the American Cancer Society, Eli Lilly, and an institutional grant from the National Institutes of Health.

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