This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (16)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

FRED A. METTLER, MD

Arch Neurol. 1964;11(5):529-542.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The opinion that parkinsonism is caused by damage of the substantia nigra was advanced by Brissaud¹ on the basis of the findings in a case of Charcot's studied by Béchet² and Blocq and Marinesco.³ In a series of 54 autopsies Trétiakoff⁴ found the substantia nigra degenerated in 16 categories of neurologic disorder including three cases of "catatonic" form of parkinsonism, nine cases of "typical" parkinsonism, and one case of unilateral parkinsonism. He concluded that damage of the substantia nigra is invariably accompanied by rigidity and tremor (and, if unilateral, that the effect was crossed) except when hemiplegia or poliomyelitis coexisted or when the patient was in extremis. Reviews of the literature^5-21 conducted since that time have substantiated a high positive correlation between nigral lesions and parkinsonism, but Trétiakoff's unitary theory of causation of parkinsonism has not been universally accepted because ( 1 ) neuropathologic changes have been . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Departments of neurology and anatomy, Columbia University.

Footnotes
Submitted for publication June 2, 1964; accepted June 30.

Aided in part by NIH grant NB 05184-01.

References 5, 6, 8, 11, 14, 15, 17-20, 22-27.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?