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Part II. Experimental Studies in the Cat

J. R. STEVENS, MD; Y. NAKAMURA, MD; V. MILSTEIN, PhD; P. OKUMA, MD; R. LLINAS, MD

Arch Neurol. 1964;11(5):463-476.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A number of striking differences between generalized and focal convulsive disorders escape present physiological and anatomical explanation. We have considered as generalized epilepsies the warningless seizures of either grand or petit mal type in which a rhythmic bilaterally synchronous 3 cycle per second (cps) spike-wave pattern is recorded on the electroencephalogram (EEG) during the interictal period. In the focal category, we include the seizures with clinical or EEG evidence of localized disturbance or onset, including psychomotor epilepsy. Of particular interest is the marked difference in the EEG response to iterative peripheral stimuli displayed by patients with these two types of seizure disorder. Induction of seizure activity by flickered light tends to be characteristic of the generalized epilepsies as defined above, while subjects with focal cortical seizures rarely demonstrate photic sensitivity. Indeed, in a recent study in our laboratory,¹⁹ individuals whose clinical history and EEG's were typical of focal epilepsy usually . . . [Full Text PDF of this Article]

Author Affiliations
PORTLAND, ORE; NEW YORK; PORTLAND, ORE; TOKYO; CANBERRA, AUSTRALIA

From the Division of Neurology, University of Oregon Medical School, Portland, Ore, and the Department of Research Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, Mass.

Footnotes
Submitted for publication June 6, 1964; accepted June 12.

Follow in Neurology, Harvard Medical School and Massachusetts General Hospital, 1959-1960 (NINDB BT-566), Associate Professor of Neurology, University of Oregon School of Medicine (Dr. Stevens); Fellow in Neurology, University of Oregon School of Medicine, 1961-1962, Department of Neurology, College of Physicians and Surgeons, Columbia University (Dr. Nakamura); Fellow in Neurology, University of Oregon School of Medicine (Dr. Milstein); University of Tokyo, School of Medicine, Department of Psychiatry (Dr. Okuma); John Curtin School of Medical Research, Neurophysiology Laboratory, The Australian National University (Dr. Llinas).

Supported by PHS NINDB grant B-1140, NONR contract 1866-41.

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