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Ultrastructure During Seizure Activity

BASIL HARRIS, MD

Arch Neurol. 1964;11(4):388-407.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

In 1946, Mellanby¹ showed that the nitrogen trichloride treatment used for bleaching (agenizing) flour acted on proteins to produce a toxic product that caused running fits (so-called canine hysteria) in dogs. This toxic substance, isolated and later synthesized by Bentley^2-4 and by Misani and Reiner,^5,6 proved to be methionine sulfoximine,^* an analogue and competitive antimetabolite of methionine. It has been shown to produce seizures in a number of species. Earlier workers, using agenized flour, have shown EEG changes but not seizures in monkeys^7-9 and neither of these changes in epileptic patients.¹⁰ Seizures have been prevented by giving large protective doses of methionine before commencing an experiment.¹¹ The observations based on agenized flour administration have been shown to be less reliable since a calculated maximum . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

Division of Neurosurgery, Department of Neurology and the Beaumont-May Institute of Neurology, Washington University School of Medicine.

Work supported by Program-Project grant NB 04513-01, National Institute of Neurological Diseases and Blindness, and in part by the Allen P. and Josephine B. Green Foundation.

Footnotes
Submitted for publication April 27, 1964; accepted May 5.

The DL-methionine-DL-sulfoximine was purchased from the California Corporation for Biochemical Research, Los Angeles.

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