This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Report of a Patient With Myasthenia Gravis for 47 Years and Histochemical Signs of Denervation

IRWIN A. BRODY, MD; W. KING ENGEL, MD

Arch Neurol. 1964;11(4):350-354.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A patient with symptoms of myasthenia gravis for 47 years was found on biopsy to have large groups of small, angulated muscle fibers. Fenichel and Shy recently observed groups of small muscle fibers in myasthenia gravis and considered this lesion indicative of a denervating process in this disease.¹ In the present case, the diagnosis of denervation was supported by histochemical studies. This case provides additional evidence that advanced signs of denervation may occur in long-standing myasthenia gravis.

Report of a Case

Clinical History.—A 50-year-old unmarried female (NIH No. 04-69-46), working as a secretary, was admitted to the National Institute of Neurological Diseases and Blindness with a chief complaint of drooping eyelids (Fig 1). Her illness began at the age of three years, when ptosis of one eyelid suddenly developed. After several years the ptosis disappeared spontaneously, but the opposite eyelid began to droop. When the patient was 10 . . . [Full Text PDF of this Article]

Author Affiliations
BETHESDA, MD

Footnotes
Submitted for publication June 26, 1964; accepted June 30.

Medical Neurology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Bethesda, Md.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?