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An Electron Microscopic Study of the Cortex

SARAH A. LUSE, MD; SIDNEY GOLDRING, MD; JAMES L. O'LEARY, MD

Arch Neurol. 1964;11(3):296-302.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The controversy concerning the site of action of strychnine as well as its mode of action has yet to be resolved. In 1933, Dusser de Barenne¹ reviewed this field and presented his own experiments pointing to a primary neuronal effect of strychnine. With the increased resolution afforded by electron microscopy, it is now feasible to examine the nervous system during strychnine convulsions in an attempt to demonstrate any accompanying morphologic alterations.

Materials and Methods

Rabbits weighing 1.5 to 2.0 kg were etherized and a craniotomy and tracheotomy performed. A small polyethylene tube was inserted through the femoral vein into the vena cava. Animals then were allowed to blow off the ether and under 3 mg per kilogram of gallamine triethiodide (Flaxedil) were maintained by artificial respiration. One pair of calomel electrodes recorded transcortically from the frontal granular cortex and another between the surface of the cerebellar vermis and its . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

Departments of Anatomy, Pathology and Neurology, the Division of Neurosurgery and the Beaumont-May Institute of Neurology, Washington University School of Medicine.

Footnotes
Submitted for publication April 30, 1964; accepted May 25.

This work was supported in part by grants from the United States Public Health Service (NB-00425 and NB-04513).

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