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ROBERT W. P. CUTLER, MD; GORDON V. WATTERS, MD; CHARLES F. BARLOW, MD

Arch Neurol. 1964;11(3):225-238.

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Introduction

During the past half century, aniline dyes and fluorescent compounds have been used to study alterations in the blood-brain barrier occurring in a variety of neuropathological conditions. Theories that were evolved to explain the absence of staining of the normal brain by acid dyes included: the impermeability of cerebrovascular endothelium to negatively charged particles,¹ a lack of brain tissue affinity for dyes,² and a barrier imposed by ground substance.³ Although the binding of certain acid and basic dyes to protein had been studied in some detail by chemists,⁴ there was no attempt in the early neurological literature to relate exclusion of dye from brain to protein impermeability. The importance of binding to plasma protein as a mechanism limiting dye penetration into brain was first emphasized by Tschirgi.⁵ More recently, Clasen et al⁶ have demonstrated a quantitative relationship between the brain uptake of Evans . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Medicine (Neurology), The University of Chicago.

Footnotes
Submitted for publication May 20, 1964; accepted June 5.

Presented in part at the annual meeting of the American Academy of Neurology, Denver, April, 1964.

Address (Dr. Cutler): The Department of Neurology, Children's Hospital Medical Center, 300 Longwood Ave, Boston, Mass 02115.

This work was supported by grant NB-2331, and NB-5172 of the Institute for Neurological Diseases and Blindness, National Institutes of Health, and by the Douglas Smith Foundation for Medical Research at The University of Chicago.

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