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Localization of Radio-Iodinated Serum Albumin in Human GliomaAn Electron-Microscopic Study
ANTHONY J. RAIMONDI, MD
Arch Neurol. 1964;11(2):173-184.
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Introduction
Since the first work on the use of gamma emitters for the localization of brain tumors,1,2 there has been a surge of activity in the investigation of the role which radioactive isotopes could play in the diagnosis of human brain tumors. Radio-iodinated serum albumin (Risa) was first introduced in 1951.3 Since that time, it has been used extensively, both on a clinical and an investigative level, in the localization of intracranial tumors.
Though it has long been known that radioiodinated serum albumin will localize within brain tumors in varying concentrations, it had never been determined at exactly which level the localization of radio-iodinated serum albumin occurred. That is to say, there was no information regarding the exact compartment (intracellular, extracellular, intravascular) of a cerebral or extracerebral tumor in which the radio-iodinated serum albumin localized.
It had been assumed that the radioiodinated serum albumin was picked up in
. . . [Full Text PDF of this Article]
Author Affiliations
CHICAGO
From the Division of Neurological Surgery of the University of Chicago Clinics.
Footnotes
Submitted for publication March 2, 1964; accepted March 31.
Aided by grants from the Douglas Smith Foundation, the Simms Research Foundation, and the Junior Auxiliary of the University of Chicago Cancer Research Foundation.
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