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Possible Relationship of Limbic Lesions and ADH Secretion

RICHARD L. ROVIT, MD; MILES H. SIGLER, MD

Arch Neurol. 1964;10(6):595-603.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

This report describes a patient with herpes simplex encephalitis who exhibited, during the acute stage of his illness, severe, transient hyponatremia with renal sodium loss presumably induced by inappropriate and excessive production of antidiuretic hormone. Although this syndrome often referred to as "cerebral salt wasting"^1-3 has been seen in patients with various brain lesions,^4-6 this is the first instance, to our knowledge, where it has been associated with verified herpes simplex encephalitis. This patient is still alive, and the exact topography of his cerebral lesion cannot be precisely delineated. Nonetheless, the clinical picture and ancillary diagnostic studies are compatible with a bilateral diffuse encephalopathy involving predominantly hippocampal and adjacent mesial temporal regions.

Because of the predilection of herpes simplex encephalitis for producing destructive lesions in those regions of the brain comprising the "limbic system"^7-9 we have discussed the relationship of the limbic system and the hypothalamic-postpituitary . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Division of Neurosurgery and the Department of Medicine, Jefferson Medical College and Hospital.

Footnotes
Submitted for publication Dec 16, 1963; accepted Feb 10, 1964.

Associate Professor of Surgery (Neurosurgery) and Head, Division of Neurological Surgery (Dr. Rovit); Instructor in Medicine, Division of Kidney Diseases and Electrolyte Metabolism (Dr. Sigler).

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