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DWAYNE REED, MD; JOHN SEVER, MD; JOHN KURTZKE, MD; LEONARD KURLAND, MD

Arch Neurol. 1964;10(4):402-410.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The search for a virus as the cause of multiple sclerosis has been extensive, but inconclusive.¹ Adams and Imagawa² recently reported that:

1. Complement fixation (CF) and neutralization (Neut) tests revealed higher titers of measles antibody^* in the sera of patients with multiple sclerosis than in those of a control group.

2. CF or Neut antibody for measles were present in the cerebrospinal fluid (CSF) of over 75% of the multiple sclerosis group and absent in the CSF of the control group.

They did not suggest that measles was the cause of multiple sclerosis, but their findings, if reproducible, could represent an important breakthrough for further investigations of a causal or of an indirect immunological relationship.

The present study was prompted by the need for independent verification of the above report, as well as the evaluation of the role of several other viruses in multiple sclerosis.

Methods . . . [Full Text PDF of this Article]

Author Affiliations
BETHESDA, MD.

Footnotes
Presented in part at the Meeting of the American Neurological Association, Atlantic City, NJ, June 12, 1963.

Assistant Chief, Epidemiology Branch, (Dr. Reed), Head, Section on Virology, Perinatal Research Branch (Dr. Sever), National Institute of Neurological Diseases and Blindness; Chief of Neurology Service, Veterans Administration Hospital, Mount Alto, Washington, DC (Dr. Kurtzke; Chief, Epidemiology Branch, National Institute of Neurological Diseases and Blindness (Dr. Kurland).

The term "antibody" is used in this paper as a collective noun.

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