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STANLEY SAMUELS, PhD

Arch Neurol. 1964;10(3):322-326.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Hereditary defects in amino acid metabolism are involved in several neurological disorders,^{1,5,7,14,17,22} and the urinary excretion pattern has been shown to be a useful diagnostic aid.⁹ Qualification of the amino acid content of a sample can best be done on an automatic analyzer. However, this technique requires 24¹⁶ to 48 hours¹⁹ for each assay for physiological fluids, with only one sample being examined at a time. This approach is unsuitable for the large-scale study of clinical populations. A screening procedure is necessary so that large numbers of patients can be routinely examined and those with a frankly normal distribution pattern eliminated without time-consuming quantitative analysis.

Rapidity and small expense have encouraged the use of circular paper chromatography as a screening technique,⁶ but this approach sacrifices resolution for speed. The "group" separation that is achieved is often inadequate. Thin-layer chromatography,²⁰ as a routine tool . . . [Full Text PDF of this Article]

Author Affiliations
BRONX, NY

Footnotes
Submitted for publication Oct 8, 1963; accepted Nov 9.

Instructor of Neurology, Albert Einstein College of Medicine.

This investigation was supported in part by Public Health Service training grant 2M-6418 from the National Institute of Mental Health and grant R-145-61 from the Cerebral Palsy Foundation and was carried out during the term of a fellowship from the National Multiple Sclerosis Society.

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