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HERBERT L. MARTIN, M.D.; ANTONIO AGUILAR, M.D.; HUNTINGTON MAVOR, M.D.; WALTER W. BURNETT, D.M.D.; FRANCIS McNAUGHTON, M.D.

AMA Arch Neurol. 1959;1(5):513-515.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since its introduction by Merritt and Putnam in 1938,¹ diphenylhydantoin (Dilantin) sodium has become one of the most widely used anticonvulsants. Although it is relatively nontoxic, gingival hyperplasia occurs in up to 50% of patients.^2,3 In most instances, proper oral hygiene effectively controls the gingival reaction. In a small number, possibly 2% or 3%, the hyperplasia may become sufficiently prominent to require some modification of dosage or gingivectomy. Not infrequently, it is impossible to find another drug or combination of drugs which has as good an anticonvulsant effect. Since no effective means of preventing or treating the severe reactions has appeared, they may remain therapeutic problems.

Our interest in this phenomenon was stimulated by a clinical report (Gaillard⁴) suggesting that gingival hyperplasia can be modified by the antihistamine chlorprophen-pyridamine maleate (Teldrin Spansules). After initiating a clinical study, we were further encouraged by the work recently reported . . . [Full Text PDF of this Article]

Author Affiliations
Burlington, Vt.

From the Neurologic Services of the Montreal Neurological Institute and the University of Vermont College of Medicine and affiliated hospitals.

Footnotes
Received for publication June 11, 1959.

Teldrin was supplied by Smith, Kline & French Laboratories, Philadelphia.

This work was supported by a Federal Provincial Rehabilitation grant from the Department of National Health and Welfare, Ottawa, Ont., Canada.

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