This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (1)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

THOMAS W. LANGFITT, M.D.; LOUIS A. FINNEY, M.D.

AMA Arch Neurol. 1959;1(3):269-281.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

In a previous report¹⁵ it was demonstrated that large doses of lysergic acid diethylamide (LSD) had no consistent effect on primary sensory evoked potentials in the cortex of the cat. However, in a recent publication Purpura²¹ reported qualitative differences in the effect of LSD on cortical evoked potentials and postulated that these were due to anatomical differences in the termination of afferents in the cortex, some ending on soma and others on dendrites. Sensory afferents end primarily on the soma of cortical neurons.

In contrast, direct electrical stimulation of the cortex produces a predominantly surface-negative wave, which is generally considered to represent the activity of apical dendrites.^5,8,10 Furthermore, it is also thought to be a postsynaptic potential analogous to the postsynaptic potential of motoneurons in the spinal cord.⁹ Also, anatomical evidence has been advanced to indicate that callosal fibers terminate primarily on dendrites or as . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Division of Neurological Surgery, The Johns Hopkins University, School of Medicine.

Present address (Dr. Finney): U. S. Naval Hospital, Chelsea, Mass.

Presented in part before the American Physiological Society, London, Ont., Canada, September, 1958.

Footnotes
Accepted for publication March 2, 1959.

Work performed under Department of Army contract.

Aided by a grant from the National Institute of Neurological Diseases and Blindness, National Institutes of Health, U. S. Public Health Service.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?