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THOMAS W. LANGFITT, M.D.; LOUIS A. FINNEY, M.D.

AMA Arch Neurol. 1959;1(3):258-268.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Several authors have reported the effects of lysergic acid diethylamide (LSD) on evoked potentials in primary sensory pathways. The areas studied were retina,² lateral geniculate body,⁸ and visual,^9,14,18 auditory,^14,18 and somatic cortex.¹⁴ There is incomplete agreement on the effects of LSD on visual and auditory cortex. Purpura¹4 found facilitation of visual cortical potentials with small doses, whereas Evarts⁸ found no significant effect with very large doses. Rovetta¹⁸ used LSD topically and intravenously in small doses and reported an absence of effect onboth visual and auditory potentials. Large doses of the drug have been used infrequently.

Numerous authors have described the effects of LSD on the electrocorticogram of several species of animals.^* There is a great variation in the dose reported to produce a significant change in frequency and amplitude, as well as disagreement regarding the character of the changes. . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Division of Neurological Surgery, The Johns Hopkins University School of Medicine.

Present address (Dr. Finney) U. S. Naval Hospital, Chelsea, Mass.

Footnotes
Accepted for publication March 2, 1959.

Work performed under Department of Army contract.

Presented in part before the American Physiological Society, London, Ont., Canada, September, 1958.

Aided by a grant from the National Institute of Neurological Diseases and Blindness, National Institutes of Health, U. S. Public Health Service.

References 3, 4, 7, 8, 10, 11, 16, 19, 20.

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