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II. Experimental Observations on Hyperosmolarity in Cats

CHARLES N. LUTTRELL, M.D.; LAURENCE FINBERG, M.D.; LOIS P. DRAWDY

AMA Arch Neurol. 1959;1(2):153-160.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Hypernatremia as a cause of acute neurological disorder is being recognized with increasing frequency.^1-11 Common clinical and metabolic features in infants with fatal outcome were described in the previous paper.¹² At autopsy, extensive venous occlusion and subarachnoid, subdural, and intracerebral bleeding were prominent findings. Mechanisms for production of these vascular changes and their relative importance in the clinical picture were not clear. It was not known, for example, to what degree hemorrhagic encephalopathy was an integral manifestation of the underlying metabolic disturbance, or whether these vascular lesions merely represented nonspecific, secondary results of transiently disturbed intracranial-pressure relationships.

Hyperosmolarity, of order of magnitude similar to that encountered in patients (375-400 mOsm/L.), produces comparable clinical alterations in experimental animals.^13,14 Within 30 minutes after intraperitoneal injection of hypertonic solutions, cats develop marked tremor, ataxia, muscle twitching, stupor, and occasional convulsions. One cat in three dies within a few hours. In . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Division of Neurological Medicine and the Department of Pediatrics, The Johns Hopkins University School of Medicine, and the Pediatric Division, The Baltimore City Hospitals.

Footnotes
Accepted for publication March 19, 1959.

Kenny Foundation Scholar (Dr. Luttrell).

This material was presented in part at the 83d Annual Meeting of the American Neurological Association in Atlantic City, June 18, 1958.

This investigation was supported by research grants, B1409 and E1230, from the National Institutes of Health, U. S. Public Health Service.

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