• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Neurology  • Cerebrovascular Disease  • Stroke  • Quality of Care  • Evidence-Based Medicine  • Patient Safety/ Medical Error  • Statistics and Research Methods  • Drug Therapy  • Adverse Effects  • Drug Therapy, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Evidence for Safety in Recurrent Stroke Prevention?

Philip B. Gorelick, MD, MPH

Arch Neurol. 2012;69(1):13-16. doi:10.1001/archneurol.2011.234

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or "statins," are frequently prescribed in clinical practice for the prevention of stroke and cardiovascular disease.¹ According to a nongeneric drug retail sales' report of the top 200 drugs sold in 2009, one of the statins ranked number 1 and another ranked number 14 in overall sales.² Statins are multimechanistic drugs with lipid-lowering properties and beneficial non–lipid-lowering effects such as modification of endothelial function, inflammatory responses, atherosclerotic plaque vulnerability, and thrombus formation. Although generally well tolerated, statins may be associated with adverse events such as muscle aches, hepatitis or hepatotoxicity, myopathy, and other complications.¹ Furthermore, a safety announcement from the US Food and Drug Administration recently informed the public about the risk of muscle injury in patients taking the highest approved dose of simvastatin (80 mg),³ and based on a pooled analysis of data from 5 statin trials, concern . . . [Full Text of this Article]

STUDY DESIGN


MAIN STUDY RESULTS

INTERPRETATION OF STUDY RESULTS

ADVICE FOR PRACTITIONERS

AUTHOR INFORMATION
Author Affiliations: Department of Neurology and Rehabilitation, Center for Stroke Research University of Illinois, College of Medicine, Chicago.

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Statins and Intracerebral Hemorrhage: A Retrospective Cohort Study
Daniel G. Hackam, Peter C. Austin, Anjie Huang, David N. Juurlink, Muhammad M. Mamdani, J. Michael Paterson, Vladimir Hachinski, Ping Li, and Moira K. Kapral
Arch Neurol. 2012;69(1):39-45.
ABSTRACT | FULL TEXT