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Central Role of -Synuclein Oligomers in Neurodegeneration in Parkinson Disease

Aleksey G. Kazantsev, PhD; Alexander M. Kolchinsky, PhD

Arch Neurol. 2008;65(12):1577-1581.

Selective death of nigrostriatal neurons, which leads to Parkinson disease, is explained by misfolding of brain protein -synuclein. Herein, we review the data supporting this concept, propose a scheme of events leading to synuclein-induced neuronal death, and discuss protein deacetylase sirtuins as new potential therapeutic targets involved in this process.

Author Affiliations: Department of Neurology, Harvard Medical School, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disease, Charlestown, Massachusetts (Dr Kazantsev); Health Front Line, Ltd, Champaign, Illinois (Dr Kolchinsky).

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