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New Mechanism of Immunomodulatory Therapy in Multiple Sclerosis

Harald H. Hofstetter, MD; Olaf Stüve, MD, PhD; Hans-Peter Hartung, MD

Arch Neurol. 2008;65(11):1417-1418.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The introduction of immunomodulatory therapy with interferon beta more than a decade ago was a major breakthrough in the treatment of multiple sclerosis (MS).¹ Therapy with interferon beta includes 3 different preparations with proved therapeutic efficacy in relapsing-remitting MS and in secondary progressive MS with superimposed relapses. Inasmuch as the etiology of MS remains largely unknown and its pathogenesis is complex, it has been challenging to identify exactly the central mechanism of action of this therapeutic agent. There are numerous proposed mechanisms of action of interferon beta by which it is thought to mediate its beneficial effects.¹ Interferon beta can influence antigen presentation by reducing the expression of major histocompatibility complex molecules and changing the expression pattern of costimulatory molecules.² In addition, it can alter the cytokine and chemokine secretion patterns of immune cells, thereby inducing primarily noninflammatory mediators³ . . . [Full Text of this Article]

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