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Restless Legs Syndrome
Confirmation of Linkage to Chromosome 12q, Genetic Heterogeneity, and Evidence of Complexity
Alex Desautels, PhD;
Gustavo Turecki, MD, PhD;
Jacques Montplaisir, MD, PhD;
Lan Xiong, MD, PhD;
Arthur S. Walters, MD;
Bruce L. Ehrenberg, MD;
Kateri Brisebois, BSc;
Amelie K. Desautels, BSc;
Yves Gingras, MSc;
William G. Johnson, MD;
Elio Lugaresi, MD;
Giorgio Coccagna, MD;
Daniel L. Picchietti, MD;
Alice Lazzarini, MD;
Guy A. Rouleau, MD, PhD
Arch Neurol. 2005;62:591-596.
Background Genes are involved in the etiology of restless legs syndrome, a common sensorimotor disorder.
Objectives To replicate and to further characterize our previously reported chromosome 12q linkage results.
Design Family linkage study.
Setting and Participants A total of 276 individuals from 19 families have been examined using a selection of markers spanning the identified candidate interval on chromosome 12q.
Results Two-point analyses of individual pedigrees indicated that 5 kindreds were consistent with linkage to chromosome 12q. When considering these 5 pedigrees along with the family in which linkage was originally reported, we observed a maximum 2-point logarithm-of-odds score of 5.67 (at  = 0.10; for marker D12S1636; autosomal recessive) and a maximum multipoint logarithm-of-odds score of 8.84 between the interval defined by markers D12S326 and D12S304. Furthermore, our results also suggest the presence of heterogeneity in restless legs syndrome as linkage was formally excluded across the region in 6 pedigrees. Interestingly, significantly higher periodic leg movements during sleep indices were observed for all probands with restless legs syndrome from linked families.
Conclusions These results support the presence of a major restless legs syndrome–susceptibility locus on chromosome 12q, which has been designated as RLS1, and also suggest that at least one additional locus may be involved in the origin of this prevalent condition.
Author Affiliations: Centre d'étude du sommeil, Hôpital du Sacré-C ur de Montréal and Centre de recherche en sciences neurologiques, Université de Montréal (Drs Desautels and Montplaisir), Research Center, Douglas Hospital (Drs Desautels, Turecki, and Gingras), Centre for Research in Neurosciences, The Montreal General Hospital, McGill University (Drs Xiong, Brisebois, and Rouleau and Ms Desautels), Montréal, Québec; The New Jersey Neuroscience Institute, JFK Medical Center, Seton Hall University School of Graduate Medical Education, Edison (Dr Walters); Department of Neurology, Tufts–New England Medical Center, Boston, Mass (Dr Ehrenberg); Department of Neurology, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick (Drs Johnson and Lazzarini); Department of Neurology, University of Bologna, Bologna, Italy (Drs Lugaresi and Coccagna); and the Carle Clinic and University of Illinois at Champaing–Urbana (Dr Picchietti).
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