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Arch Neurol. 2005;62:20-22.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

It is a frequently made observation that patients with Alzheimer disease (AD) tend to be thinner than healthy elderly individuals. When and why patients with AD lose weight have long been intriguing questions with elusive answers. The processes leading to weight loss are likely complex, differing to some extent among patients, by disease stage, and by degree of nutritional support. Weight loss in AD has negative prognostic implications, being associated with greater disease severity, a faster clinical progression rate, and increased mortality. In contrast, modest weight gain is associated with a slower progression rate and reduced mortality.¹

For some patients with dementia, it is becoming increasingly clear when weight loss starts to occur. The article by Stewart et al² in this issue of Archives of Neurology provides evidence that men who develop dementia (both AD and vascular dementia) tend to start losing weight at least several years prior to their . . . [Full Text of this Article]

AUTHOR INFORMATION

Michael Grundman, MD, MPH

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Arch Neurol. 2005;62(1):55-60.
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