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Arch Neurol. 2008;65(12):1654.

Error in Figure. In the article titled "Embryonic Myosin Heavy-Chain Mutations Cause Distal Arthrogryposis and Developmental Myosin Myopathy That Persists Postnatally," by Tajsharghi et al, published in the August Archives (2008;65[8]:1083-1090), there was an error in Figure 8 on page 1089 and in the text wherever the mutation T178M is mentioned. The heterozygous missense mutation C602T in exon 5 was erronously described as changing the highly conserved threonine at position 178 to methionine. In fact, the mutation leads to the amino acid substitution threonine to isoleucine at position 178. The last 2 nucleotides in exon 5 (AC) together with the first nucleotide in exon 6 (C) code for threonine. Therefore, the mutation changed codon 178 from ACC coding for threonine to ATC coding for isoleucine. This is restated in a new figure legend and shown in the corrected figure.

View larger version (13K): [in this window] [in a new window] [as a PowerPoint slide]   Figure 8. Genomic structure of MYH3 with location of the distal arthrogryposis-causing mutations and the embryonic MyHC protein. The 3 mutations reported herein are indicated in red. The major proteolytic fragments S1, S2, and light meromyosin (LMM) of the MyHC protein are indicated.

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