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Arch Neurol. 2002;59:202.

In the Original Contribution by Parvathy et al titled "Correlation Between Aßx-40–, Aßx-42–, and Aßx-43–Containing Amyloid Plaques and Cognitive Decline," published in the December issue of ARCHIVES (2001;58:2025-2032), Figure 1 and Figure 5 had errors in the body of the figure and its accompanying legend. We are reproducing the correct figures and legends here (Figure 1 and Figure 5). In the legends to Figures 1 through 5, the sentence that reads "AßC40, AßC42, and AßC43 are antibodies reactive to amyloid ßx-40." should have read: "AßC40, AßC42, and AßC43 are antibodies reactive to amyloid ßx-40, amyloid ßx-42, and amyloid ßx-43, respectively. In addition, the second mention of the lead author's name was misspelled in the affiliation footnote at the bottom left on page 2025. It should have read Dr Parvathy. The ARCHIVES regrets these errors.

View larger version (32K): [in this window] [in a new window] Figure 1. Characterization of antibodies. AßC40, AßC42, and AßC43 are antibodies reactive to amyloid ßx-40, amyloid ßx-42, and amyloid ßx-43, respectively. Specificity of antibodies AßC40, AßC42, and AßC43 was determined by dot blotting (A), immunoblotting (B), and enzyme-linked immunosorbent assay (C). Synthetic Aß1-40, Aß1-42, or Aß1-43 was either spotted on a nitrocellulose membrane (A) or electrophoresed on a Tris-tricine gel and transferred to a nitrocellulose membrane (B). The membranes were probed with the indicated antibodies and detected using horseradish peroxidase–conjugated secondary antibody with enhanced chemiluminescent reagent. In part C indicated amounts of synthetic Aß1-40, Aß1-42, and Aß1-43 peptides were coated onto enzyme-linked immunosorbent assay plates and incubated with antibody. Bound antibody was detected using a calorimetric assay.

View larger version (13K): [in this window] [in a new window] Figure 5. Relative proportion of amyloid ß (Aß) plaque types. The number of cored and diffuse plaques in double-labeled sections stained with either AßC40 and AßC42 (A) or AßC42 and AßC43 (B) antibodies was determined and is given as a percentage of total plaques counted in each condition. In each condition, the number of plaques containing either 1 or 2 Aß variants was determined. AßC40, AßC42, and AßC43 are antibodies reactive to amyloid ßx-40, amyloid ßx-42, and amyloid ßx-43, respectively.