Surgery for Parkinson Disease
Lang (SEE ARTICLE) provides a review of neurotherapeutics of surgical therapies for Parkinson disease. The merits and demerits, advantages and limitations of each surgical approach are carefully considered in this clinically valuable review.
Yeast and the Brain
Walberg (SEE ARTICLE) reviews how yeast genetics is relevant to the study of neuroscience and neurologic disease. The area is a growing and dynamic one that offers understanding of gene expression in the nervous system.
Coexisting Causes of Stroke
Moncayo and colleagues (SEE ARTICLE) analyze data from a prospective acute stroke registry documenting the uncommon coexistence of multiple potential causes of cerebral infarction. This careful and insightful study will be of considerable value to neurologists considering issues of stroke pathogenesis. Caplan (SEE ARTICLE) provides an editorial comment.
Contributions of Lewy Body Inclusions to Dementia
Haroutunian and colleagues (SEE ARTICLE) , in a careful neuropathologic-clinical correlation, conclude that Lewy body inclusions appear to contribute significantly to cognitive deficits in patients with dementia of Alzheimer disease type. Lewy bodies are not innocent.
Cytokine Expression in Alzheimer Disease
Luterman and colleagues (SEE ARTICLE) provide new information related to cytokine expression during the clinical course of Alzheimer disease. Their findings have implications for design of anti-inflammatory treatment strategies.
Computed Tomographic Perfusion Imaging in Acute Stroke
Röther and colleagues (SEE ARTICLE) show the value of using dynamic single-slice computed tomographic perfusion imaging in detecting deficits in acute stroke. As this imaging technique is broadly available, it may play a useful role in acute stroke management.
Motor Neuron Disease in Ireland
Traynor and colleagues (SEE ARTICLE) review their extensive experience in evaluating patients with motor neuron disease in Ireland and the appropriateness of the El Escorial and Airlie House diagnostic criteria.
-Endorphin Levels in Multiple Sclerosis
Gironi and colleagues (SEE ARTICLE) have measured 
-endorphin levels in clinically inactive patients with multiple sclerosis. An increase of -endorphin levels during a clinical relapse may represent an important control mechanism.
Activation Markers in Multiple Sclerosis
Khoury and colleagues (SEE ARTICLE) have measured activation markers on peripheral blood T cells to correlate with disease activity in patients with multiple sclerosis. A linkage between peripheral lymphocyte activation and disease activity is described.
Treating Tics With Toxin
Kwak and colleagues (SEE ARTICLE) provide support for the effectiveness of botulinum toxin A injections for the treatment of tics in patients with Tourette syndrome. The criteria and expected benefits are discussed.
Typing Tremor
Louis and colleagues (SEE ARTICLE) point out that essential tremor is not a homogeneous condition. Subtypes are defined and potential different causes and genetic heterogeneity are discussed. Therapies need to be considered with these points in mind.
A Patient With 2-Repeat Expansion Mutations
Nokelainen and colleagues (SEE ARTICLE) describe a patient having triplet repeats with myotonic dystrophy and progressive myoclonus epilepsy. This unusual and unfortunate genetic occurrence is put into perspective at the molecular level. William Johnson, MD (SEE ARTICLE) , provides an editorial comment.
