Physicians in the United States, Canada, and Mexico
Physicians with current and valid licenses in the United States, Canada, or Mexico who read any 3 of the selected continuing medical education (CME) articles in this issue of Archives of Neurology, complete the CME Evaluation Form, and fax it to the number or mail it to the address at the bottom of the CME Evaluation Form are eligible for category 1 CME credit. There is no charge.
The American Medical Association (AMA) is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians. The AMA designates this educational activity for up to 3 hours of category 1 CME credit per Archives of Neurology issue toward the AMA Physician's Recognition Award (PRA). Each physician should claim only those hours of credit that were actually spent in this educational activity.
Physicians in Other Countries
Physicians with current and valid licenses in the United States, Mexico, or Canada are eligible for CME credit even if they live or practice in other countries. Physicians licensed in other countries are also welcome to participate in this CME activity. However, the PRA is only available to physicians licensed in the United States, Canada, or Mexico.
Statement of Educational Purpose
The Archives of Neurology provides new evidence for the practice of neurology, neurosurgery, and other specialties whose goal is to improve the neurological health of all people. Original contributions, neurological reviews, neurology and public health, and history of neurology are among the categories of articles published, but all contributions receive a sympathetic reading by the Chief Editor. The journal's editorial board sets the initial framework for the types of articles published, which is then modified by feedback from editors, external peer reviewers, authors, and readers. We are keen to receive submissions from practicing neurologists to provide new insight for colleagues.
We want our readers to assess each article critically; this CME activity is active, not passive. Does the article contribute in some way to the practice of neurology? How could you modify your practice style to incorporate what you have learned? How can you acquire more information, challenge the authors' conclusions, or verify what you have read? Which of the articles in each issue is least helpful in your quest for the best and most applicable evidence?
Earning Credit and CME Evaluation Form
To earn 1 hour of category 1 CME credit, you should read any 3 of the CME articles listed below and complete the CME Evaluation Form. To earn 3 hours of credit, read all of the articles listed below and complete the CME Evaluation Form. The CME Evaluation Form must be submitted within 4 weeks of the issue date. A certificate awarding up to 3 hours of category 1 CME credit will be faxed or mailed to you; it is then your responsibility to maintain a record of credit received. Questions about CME credit processing should be directed to the Blackstone Group; tel: (312) 419-0400, ext 225; fax: (312) 269-1636.
CME Articles in This Issue of Archives of Neurology
The articles listed below may be read for CME credit.
Role of the Low-density Lipoprotein Receptor–Related Protein in 
-Amyloid Metabolism and Alzheimer Disease (SEE ARTICLE)
Educational Objective: To recognize the role of the low density lipoprotein receptor-related protein in Alzheimer disease.
The Molecular Basis for Understanding Neurotrophins and Their Relevance to Neurologic Disease (SEE ARTICLE)
Educational Objective: To learn about advances in neurotrophin biology relevant to neurologic disorders.
National Institutes of Health Consensus Conference: Tuberous Sclerosis Complex (SEE ARTICLE)
Educational Objective: To read about consensus recommendations for diagnostic criteria and other aspects of tuberous sclerosis complex.
Hereditary Motor and Sensory Neuropathy Type 2C Is Genetically Distinct From Types 2B and 2D (SEE ARTICLE)
Educational Objective: To understand recent advances in the neurogenetics of hereditary motor and sensory neuropathy.
Predicting Conversion to Alzheimer Disease Using Standardized Clinical Information (SEE ARTICLE)
Educational Objective: To identify which patients with questionable Alzheimer disease are most likely to "convert" to Alzheimer disease over time.
Stereotaxic Injection of IgG From Patients With Alzheimer Disease Initiates Injury of Cholinergic Neurons of the Basal Forebrain (SEE ARTICLE)
Educational Objective: To identify the role of IgG in Alzheimer disease.
Prediction of Spinal Epidural Metastases (SEE ARTICLE)
Educational Objective: To identify patients with cancer and back pain in whom MRI can safely be omitted.
No Association Between a Presenilin 1 Polymorphism and Alzheimer Disease (SEE ARTICLE)
Educational Objective: To learn more about the neruogenetics of late-onset Alheimer disease.
Electroecephalographic, Volumetric, and Neuropsychological Indicators of Seizure Focus Lateralization in Temporal Lobe Epilepsy (SEE ARTICLE)
Educational Objective: To determine the value of presurgical EEG, MRI, and neuropsychological assessment in the localization of seizure focus.
The Relative Frequency of "Dementia of Unknown Etiology" Increases With Age and Is Nearly 50% in Nonagenarians (SEE ARTICLE)
Educational Objective: To determine the clinical and pathological features of dementias not due to well-characterized dementias.
Ethnic Differences in Essential Tremor (SEE ARTICLE)
Educational Objective: To identify ethnic differences in clinical manifestations of essential tremor.
Clinical Characteristics of Pramipexole-Induced Peripheral Edema (SEE ARTICLE)
Educational Objective: To study peripheral edema in patients taking pramipexole.
Hereditary Spastic Paraplegia and Hereditary Ataxia, Part 2: A Family Demonstrating Various Phenotypic Manifestations With the SCA3 Genotype (SEE ARTICLE)
Educational Objective: To read about the clinical, pathological, and genetic aspects of a family with dominantly inherited ataxic motor syndromes first reported in 1951.
Three Families With Polyneuropathy Associated With Monoclonal Gammopathy (SEE ARTICLE)
Educational Objective: To read about familial occurrence of polyneuropathy associated with monoclonal gammopathy.
Idiopathic Stabbing Headache Associated With Monocular Visual Loss (SEE ARTICLE)
Educational Objective: To read about a case of idiopathic stabbing headache associated with monocular visual loss.
