Physicians in the United States, Canada, and Mexico
Physicians with current and valid licenses in the United States, Canada, or Mexico who read any 3 of the selected continuing medical education (CME) articles in this issue of Archives of Neurology, complete the CME Evaluation Form, and fax it to the number or mail it to the address at the bottom of the CME Evaluation Form are eligible for category 1 CME credit. There is no charge.
The American Medical Association (AMA) is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians. The AMA designates this educational activity for up to 3 hours of category 1 CME credit per Archives of Neurology issue toward the AMA Physician's Recognition Award (PRA). Each physician should claim only those hours of credit that were actually spent in this educational activity.
Physicians in Other Countries
Physicians with current and valid licenses in the United States, Mexico, or Canada are eligible for CME credit even if they live or practice in other countries. Physicians licensed in other countries are also welcome to participate in this CME activity. However, the PRA is only available to physicians licensed in the United States, Canada, or Mexico.
Statement of Educational Purpose
The Archives of Neurology provides new evidence for the practice of neurology, neurosurgery, and other specialties whose goal is to improve the neurological health of all people. Original contributions, neurological reviews, neurology and public health, and history of neurology are among the categories of articles published, but all contributions receive a sympathetic reading by the Chief Editor. The journal's editorial board sets the initial framework for the types of articles published, which is then modified by feedback from editors, external peer reviewers, authors, and readers. We are keen to receive submissions from practicing neurologists to provide new insight for colleagues.
We want our readers to assess each article critically; this CME activity is active, not passive. Does the article contribute in some way to the practice of neurology? How could you modify your practice style to incorporate what you have learned? How can you acquire more information, challenge the authors' conclusions, or verify what you have read? Which of the articles in each issue is least helpful in your quest for the best and most applicable evidence?
Earning Credit and CME Evaluation Form
To earn 1 hour of category 1 CME credit, you should read any 3 of the CME articles listed below and complete the CME Evaluation Form. To earn 3 hours of credit, read all of the articles listed below and complete the CME Evaluation Form. The CME Evaluation Form must be submitted within 4 weeks of the issue date. A certificate awarding up to 3 hours of category 1 CME credit will be faxed or mailed to you; it is then your responsibility to maintain a record of credit received. Questions about CME processing should be directed to The Blackstone Group; fax: (312) 269-1636.
CME Articles in This Issue of Archives of Neurology
The articles listed below may be read for CME credit.
Alzheimer Disease: Mouse Models Pave the Way for Therapeutic Opportunities (SEE ARTICLE)
Educational Objective: To recognize the importance of research into molecular mechanisms of Alzheimer disease.
Cortical and Subcortical Interhemispheric Interactions Following Partial and Complete Callosotomy (SEE ARTICLE)
Educational Objective: To understand the clinical consequences of callosotomy.
Clinical Criteria for the Diagnosis of Vascular Dementia: A Multicenter Study of Comparability and Interrater Reliability (SEE ARTICLE)
Educational Objective: To read about efforts to standardize the diagnosis of vascular dementia.
Striatal Dopamine Transporter Binding Assessed by [I-123]IPT and Single Photon Emission Computed Tomography in Patients With Early Parkinson Disease (SEE ARTICLE)
Educational Objective: To detect preclinical Parkinson disease using specific binding to dopamine transporters.
Association Between Angiotensin-Converting Enzyme and Alzheimer Disease (SEE ARTICLE)
Educational Objective: To determine whether the angiotensin-converting enzyme is associated with risk of Alzheimer disease.
A Novel Missense Mutation (W797R) in the Myophosphorylase Gene in Spanish Patients With McArdle Disease (SEE ARTICLE)
Educational Objective: To learn more about the neurogenetics of McArdle disease.
Intracranial Volume and Alzheimer Disease: Evidence Against the Cerebral Reserve Hypothesis (SEE ARTICLE)
Educational Objective: To investigate the association of total intracranial volume and Alzheimer disease.
Differences Between Pick Disease and Alzheimer Disease in Clinical Appearance and Rate of Cognitive Decline (SEE ARTICLE)
Educational Objective: To recognize the clinical characteristics of Pick disease.
Lack of an Association of Estrogen Receptor 
Gene Polymorphisms and Transcriptional Activity With Alzheimer Disease (SEE ARTICLE)
Educational Objective: To learn about neurogenetics relevant to estrogen therapy and Alzheimer disease.
Very Late-Onset Friedreich Ataxia Despite Large GAA Triplet Repeat Expansions (SEE ARTICLE)
Educational Objective: To understand the neurogenetics of very late-onset Friedreich ataxia.
Mechanism in Progressive Lacunar Infarction: A Case Report With Magnetic Resonance Imaging (SEE ARTICLE)
Educational Objective: To investigate lacunar infarction magnetic resonance imaging.
Cerebral Venous Thrombosis Associated With Epoetin Alfa Therapy (SEE ARTICLE)
Educational Objective: To read about cerebral venous thrombosis in a patient treated with erythropoietin.
Tolcapone and Hepatotoxic Effects (SEE ARTICLE)
Educational Objective: To learn about hepatic dysfunction and tolcapone therapy.
