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Arch Neurol. 1999;56:395.

Neuro-Oncology 1999
Nine major articles appear in this issue of Neuro-Oncology 1999. The editorial by Rosenberg (SEE ARTICLE) highlights the main points of each of these review articles. Current conventional therapies for brain tumors are presented in the papers by Levin (SEE ARTICLE) , Packer (SEE ARTICLE) ,Shapiro (SEE ARTICLE) , and Perry et al (SEE ARTICLE) . The need for adequate pain control in patients with cancer is emphasized poignantly by Foley (SEE ARTICLE) . Dalmau and Posner (SEE ARTICLE) describe the neurobiological importance of paraneoplastic-related autoantibodies and their clinical implications. The theme issue concludes with 3 molecular studies byHill et al (SEE ARTICLE) , Fueyo et al (SEE ARTICLE) , and Fathallah-Shaykh (SEE ARTICLE) . Molecular genetic changes in the glioma cell are described that offer unique strategies on which to capitalize in the development of effective new molecular therapies.

Titan and Myasthenia Gravis (MG)
Skeie and colleagues (SEE ARTICLE) describe patients with MG and without titan antibodies, and the natural history of MG. The role of tumor necrosis factor in the causation of disease is carefully reviewed. The molecular immunology of MG continues to unfold.

Sympathetic Reflexes in Cerebellar Disease
Shindo et al (SEE ARTICLE) describe prolonged reflex latencies of skin–sympathetic nerve activity in patients with cerebellar degeneration. These measurements may be useful in evaluating sympathetic function in this subset of patients.

The Corpus Callosum and Alzheimer Disease
Teipel and colleagues (SEE ARTICLE) , using positron–emission tomographic scans, record corpus callosum atrophy in patients with Alzheimer disease with associated reduced regional glucose metabolism. These authors find a correlation between metabolic and corpus callosum ratios suggesting loss of interhemispheric projecting neurons. These observations are unique and important in defining defects in neuronal projection systems.

Gabapentin and Propranolol in Treating Tremor
Gironell and colleagues, (SEE ARTICLE) in a rigorous and thorough study, show that gabapentin is a useful drug in the treatment of essential tremor.