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COMMENTS AND OPINIONS
In Vivo Confocal Microscopy of Corneal Stromal Nerves in Patients With Peripheral Neuropathy—Reply
Patrice H. Lalive, MD;
André Dosso, MD
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In reply
We thank Patel and McGhee for their comments. We agree that the results of an assessment of corneal nerve changes by in vitro confocal microscopy (IVCM) should be interpreted with caution. This new approach definitely still requires validation in larger cohorts of patients and the establishment of specific criteria allowing accurate qualification and quantification of corneal nerve alterations. In this regard, the recent publication by Visser et al1 will certainly help to better delineate both the usefulness and the limitations of corneal IVCM.
Nevertheless, the main point of our article concerned observation of the changes in the stromal nerve morphology over time in the same patient. Indeed, the changes in stromal nerves we described were not only based on a comparison of the patient with a healthy control (Figure, B) but also on the evolution of the nerves' morphology observed over . . . [Full Text of this Article] AUTHOR INFORMATION
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ABSTRACT
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RELATED LETTER
In Vivo Confocal Microscopy of Corneal Stromal Nerves in Patients With Peripheral Neuropathy
Dipika V. Patel and Charles N. J. McGhee
Arch Neurol. 2009;66(9):1179-1180.
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