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COMMENTS AND OPINIONS
In Vivo Confocal Microscopy of Corneal Stromal Nerves in Patients With Peripheral Neuropathy
Dipika V. Patel, PhD, MRCOphth;
Charles N. J. McGhee, PhD, FRCS, FRCOphth
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We read with great interest the article by Lalive et al1 that elegantly described corneal stromal nerve alterations imaged by laser scanning in vivo confocal microscopy (LSCM) in a patient with peripheral autoimmune neuropathy. The case clearly illustrates the potential application of this technology to follow disease progression and assess responses to treatment, an area in which we and a small number of research groups are also interested.
However, the authors' suggestion that LSCM may be useful in the early detection of peripheral neuropathy should be approached with caution. A recent study described a similar population of thin, tortuous nerves with a beaded appearance in the corneal anterior and midstroma of healthy subjects.2 A possible distinction between the nerves described by Lalive et al and those in corneas without peripheral neuropathy is the difference in nerve diameter. However, . . . [Full Text of this Article] AUTHOR INFORMATION
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RELATED ARTICLE
Peripheral Autoimmune Neuropathy Assessed Using Corneal In Vivo Confocal Microscopy
Patrice H. Lalive, André Truffert, Michel R. Magistris, Théodor Landis, and André Dosso
Arch Neurol. 2009;66(3):403-405.
ABSTRACT
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RELATED LETTER
In Vivo Confocal Microscopy of Corneal Stromal Nerves in Patients With Peripheral Neuropathy—Reply
Patrice H. Lalive and André Dosso
Arch Neurol. 2009;66(9):1180.
EXTRACT
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