This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related letter  • Related article  • Similar articles in this journal  Topic Collections  • Neurology  • Prion Diseases  • Diagnosis  • Alert me on articles by topic  Social Bookmarking   What's this?

Jed Barash, MD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The recent article by Appleby et al¹ demonstrated an interesting phenotypic classification of sporadic Creutzfeldt-Jakob disease (sCJD). Of particular note were the characteristics of patients with the affective variant, who reported psychiatric symptoms in the first week of illness. These individuals also experienced the longest median survival time of all phenotypes (421 days). Interestingly, the early psychiatric presentation and prolonged survival of affective cases are reminiscent of variant CJD (vCJD), an entity associated with an exposure to the agent carrying bovine spongiform encephalopathy.² Although nearly all vCJD cases have emerged in Europe and demonstrate distinct clinical features (including a mean age at onset in the third decade of life), these similarities and additional data presented by Appleby and colleagues do raise concern about our ability to promptly diagnose vCJD in the United States. In particular, the patients with the affective variant experienced the longest median duration of . . . [Full Text of this Article]

AUTHOR INFORMATION



CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED LETTER

Identification of Creutzfeldt-Jakob Disease Variants—Reply
Brian S. Appleby, Kristin K. Appleby, Barbara J. Crain, Peter V. Rabins, Chiadi U. Onyike, and Mitchell T. Wallin
Arch Neurol. 2009;66(8):1045-1046.
EXTRACT | FULL TEXT  

RELATED ARTICLE

Characteristics of Established and Proposed Sporadic Creutzfeldt-Jakob Disease Variants
Brian S. Appleby, Kristin K. Appleby, Barbara J. Crain, Chiadi U. Onyike, Mitchell T. Wallin, and Peter V. Rabins
Arch Neurol. 2009;66(2):208-215.
ABSTRACT | FULL TEXT