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APOE 2/4 Genotype a Risk Factor for Primary Progressive Aphasia in Women

Antonio Daniele, MD, PhD; Maria G. Matera, BiolD; Davide Seripa, BiolD; Adele Acciarri, MD; Alessandra Bizzarro, MD, PhD; Alberto Pilotto, MD; Carlo Masullo, MD

Arch Neurol. 2009;66(7):910-912.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Frontotemporal dementia (FTD) is a clinically and pathologically heterogeneous entity characterized by focal degeneration of the cerebral cortex, which may present with behavioral and cognitive symptoms, especially linguistic deficits. Genetic factors might play an important role in FTD, which is a relatively common cause of early-onset dementia. We reported that the frequency of the 2/4 genotype of the apolipoprotein E (APOE; GenBank AF286472) gene is significantly increased in primary progressive aphasia (PPA),¹ one of the syndromes associated with FTD. Primary progressive aphasia is characterized by progressive language impairment, while other cognitive functions remain relatively intact for at least the first 2 years of the course.²

We examined 125 patients with a clinical diagnosis of probable FTD,³ including a subgroup of 39 patients . . . [Full Text of this Article]

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