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COMMENTS AND OPINIONS
Can Treatment With Nonsteroidal Anti-inflammatory Drugs Protect From Dementia?—Reply
Barbara K. Martin, PhD;
Jason Brandt, PhD;
John C. S. Breitner, MD, MPH;
Suzanne Craft, PhD;
Denis Evans, MD;
Robert Green, MD;
Michael Mullan, MD;
Steven Piantadosi, MD, PhD;
Christine Szekely, PhD
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In reply
Results regarding the a priori primary hypothesis of ADAPT, that administration of the tested NSAIDs would reduce the incidence of clinically diagnosed AD, were reported in a previous article.1 We regret any possible lack of clarity on this point. In our later article, we addressed the major secondary aim of the trial by comparing the treatment groups with respect to their longitudinal cognitive function scores.
We agree that the early termination of ADAPT "limits the conclusions that can be drawn" and that we cannot say definitively from the results of the trial whether NSAIDs can prevent dementia or decline in cognitive function. However, we do not agree that the ability to test hypotheses regarding differences in . . . [Full Text of this Article] AUTHOR INFORMATION
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RELATED LETTER
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