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Anand Viswanathan, MD, PhD

Arch Neurol. 2009;66(4):520-522.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

JAMA

High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Controlled Trial

Paul S. Aisen, MD; Lon S. Schneider, MD, MS; Mary Sano, PhD; Ramon Diaz-Arrastia, MD, PhD; Christopher H. van Dyck, MD; Myron F. Weiner, MD; Teodoro Bottiglieri, PhD; Shelia Jin, MD, MPH; Karen T. Stokes, BA, BS; Ronald G. Thomas, PhD; Leon J. Thal, MD; for the Alzheimer Disease Cooperative Study

Context:   Blood levels of homocysteine may be increased in Alzheimer disease (AD) and hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct neurotoxic mechanisms. Even in the absence of vitamin deficiency, homocysteine levels can be reduced by administration of high-dose supplements of folic acid and vitamins B₆ and B₁₂. Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline.

Objective:   To determine . . . [Full Text of this Article]

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