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COMMENTS AND OPINIONS
Notice of Incomplete Referencing—Reply
Raymond Voltz, MD
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In reply
In the May 2009 issue of the Archives of Neurology, we published a study describing cross-reactive T cells between tumor and nervous system in a patient with a paraneoplastic syndrome.1 This detailed molecular analysis of lymphocytes' T-cell receptor complementarity-determining region 3 sequence was retrieved from this patient's tumor, peripheral blood, and cerebrospinal fluid, describing ontogenetically distinct, but functionally identical, clones in the different tissues.
The cerebrospinal fluid of this patient was also analyzed for MRZ (measles, rubella, zoster) reaction as 1 of a cohort of 76 patients, without specific reference to individual patients.2 The full neurological and oncological details of this patient can now also be found in another article,3 which describes the antibody status in serum and imaging data (fludeoxyglucose [FDG]–PET). This patient is unusual both oncologically (good tumor prognosis of an adult neuroblastoma) and neurologically (long-term survivor of anti-Hu associated paraneoplastic syndrome).
. . . [Full Text of this Article] AUTHOR INFORMATION
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Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue
Hannah L. Pellkofer, Raymond Voltz, Norbert Goebels, Reinhard Hohlfeld, and Klaus Dornmair
Arch Neurol. 2009;66(5):655-658.
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