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Brian Avants, PhD; Alea Khan; Leo McCluskey, MD, MBE; Lauren Elman, MD; Murray Grossman, MD, EdD

Arch Neurol. 2009;66(1):138-139.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) presents with impaired language or behavior and declining motor function. Frontotemporal lobar degeneration with ubiquinated transactivating responsive sequence DNA-binding protein (TDP-43) inclusions is found postmortem in the affected brain areas of patients with ALS, FTD/ALS, and many patients with FTD.¹ Prior magnetic resonance imaging (MRI) observations revealed cross-sectional atrophy in the motor and/or premotor cortices of patients with FTD/ALS,² while a longitudinal study using diffusion tensor imaging revealed corticospinal tract changes.³ We used high-resolution diffeomorphic image normalization^4-5 and serial MRI to provide the first assessment of longitudinal cortical atrophy in patients with FTD/ALS relative to controls.

Methods

Subjects

We contrasted 4 elderly controls with 4 patients with FTD/ALS, performed by an experienced neurologist (M.G.) at the University of Pennsylvania Department of Neurology. Two trained reviewers (M.G. and L.M.) . . . [Full Text of this Article]

Imaging

Imaging Normalization and Longitudinal Atrophy Assessment

Results

Comment

AUTHOR INFORMATION


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