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COMMENTS AND OPINIONS
Nutrition and Ischemic Stroke—Reply
Sung-Hee Yoo, RN, MS;
Dong-Wha Kang, MD, PhD
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In reply
The visceral proteins, as a compartment reflecting protein-energy malnutrition, have long been used for nutritional assessment. In particular, serum albumin, an easily feasible biomarker in clinical settings, has been widely used as a marker of undernutrition in various clinical situations including end-stage renal disease,1-2 cancer,3 and stroke.
Of course, the interpretation of hypoalbuminemia needs caution, because albumin may decrease in comorbidities other than undernutrition, and has a long half-life. Transferrin and prealbumin, with shorter half-lives, have also been used for nutritional assessment. In particular, prealbumin has a much shorter half-life and a smaller serum pool than albumin and is not easily affected by comorbidities or hydration status; therefore, it has recently been proposed as a rapid-turnover protein reflecting real-time nutritional status.4-5
As Kliewer commented, in metabolic stress condition like inflammation, visceral proteins may decrease and C-reactive protein (CRP) may increase . . . [Full Text of this Article] AUTHOR INFORMATION
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