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Inverse Ocular Bobbing in a Patient With Encephalitis Associated With Antibodies to the N-methyl-D-aspartate Receptor
Haruo Shimazaki, MD, PhD;
Mitsuya Morita, MD, PhD;
Imaharu Nakano, MD, PhD;
Josep Dalmau, MD, PhD
Arch Neurol. 2008;65(9):1251.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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A 30-year-old woman presented with headache, fever, disorientation, and recent memory disturbance. Brain magnetic resonance imaging showed fluid-attenuated inversion recovery hyperintense abnormalities in both hippocampi, without abnormal findings in other areas of the brain or brainstem.1 The patient subsequently developed tonic convulsions, restlessness, anxiety, and hypoventilation that led to the use of sedation and mechanical ventilation. While in the intensive care unit, inverse ocular bobbing and skew deviation were transiently observed (Figure) (a video is available here). Antibodies to NR1/NR2 heteromers of the N-methyl-D-aspartate receptor were identified in her serum and cerebrospinal fluid. After immunotherapy and removal of an ovarian teratoma, all symptoms started to improve and the patient was able to return to her job 1 year later.
Figure appears in full text version.
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