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Salvatore DiMauro, MD; Julio Montoya Villaroya, PhD

Arch Neurol. 2008;65(8):1130.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Giuseppe Attardi was neither a neurologist nor a practicing physician, though he obtained his medical degree from the University of Padua in 1947. However, his pioneering work in mitochondrial biology had a tremendous effect on our understanding of human mitochondrial diseases. Therefore, his death, which abruptly interrupted a long but still vibrant research career, is as much a loss for biology in general as it is for neurology. Dr Attardi's monumental contributions to our knowledge of the "other genome," mitochondrial DNA (mtDNA), include the discovery of mitochondrial RNA (which accounts for only 0.5% of the total cellular RNA [a very important needle in a very big haystack]), the characterization of mitochondrial ribosomes, the definition of mtDNA transcription, the punctuation role of mitochondrial transfer RNA in the processing of the polycistronic precursor RNA, and the identification of all 13 proteins encoded by mtDNA. More . . . [Full Text of this Article]

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