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COMMENTS AND OPINIONS
Antihypertensive Medications Influence the Rate of Conversion From Mild Cognitive Impairment to Alzheimer Disease
Luca Rozzini, MD;
Barbara Vicini Chilovi, MD;
Marco Trabucchi, MD, PhD;
Alessandro Padovani, MD, PhD
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We read with interest the article by Reitz et al1 showing that a history of hypertension is related to a higher risk of mild cognitive impairment (MCI). To further discuss this topic, we analyzed 80 subjects consecutively recruited in our clinic who met the operational criteria for MCI at 2 years' follow-up. Subjects with conversion to Alzheimer disease over time were classified as having dementia; subjects who remained unchanged during follow-up were defined as stable. Sociodemographic and clinical characteristics are shown in the Table. When analyzed in a logistic regression model, older age (> 72 years) and Alzheimer Disease Assessment Scale, Cognitive Subscale basal score (> 9.5 points) were independently associated with the conversion to Alzheimer disease (older age: odds ratio, 9.9; 95% confidence interval, 2.2-43.9; P = .003; and Alzheimer Disease Assessment Scale, Cognitive Subscale basal . . . [Full Text of this Article]AUTHOR INFORMATION
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